Methods and strategies for optimizing microbiological fermentation
The recent revival of interest in microbial fermentation for the production of biologics can be attributed to several key factors.
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Fermentors and bioreactors: anaerobic and aerobic cultivation
Fermentation is understood as the whole set of sequential operations from the introduction of seed material into a pre-prepared and heated medium to the required temperature and to the completion of the process of cell growth or biosynthesis of the target product. At the end of fermentation, a complex mixture is formed, consisting of producer…
Features of BRS fermenters and bioreactors
The stirrer is one of the most important components of fermenters and bioreactors. The optimal design of the stirrer (the number of blades and their position), as well as the speed of its rotation, ensure the best mass transfer during cell cultivation.
Ultrafiltration in downstream bioprocessing (DSP)
Membrane filtration is a pressure separation process that uses membranes to separate components in a liquid solution or suspension based on their size and differences in charge. Ultrafiltration is a type of membrane filtration in which hydrostatic pressure forces liquid against a semi-permeable membrane. Solvent and low molecular weight solutes pass through the membrane and are called permeate, while suspended solids and high molecular weight solutes are retained (retentate).
Production of biopharmaceuticals: upstream and downstream processing
The COVID-19 pandemic has affected many areas of life, including the development, market launch and production of life-saving pharmaceuticals. Demand for equipment and consumables for the production of monoclonal antibodies, viral vectors and other biopharmaceuticals has grown exponentially.
How to buy a right fermenter: BRS guiding principles
Regarding the current state of the industry, many manufacturers of machinery and equipment, continue to provide consumers with a convenient service and product. As manufactures focus on the value of the product, place of production in terms of regulation standards, design and keeping silent about the “cost of ownership.” In order to reduce the cost of goods, the equipment is assembled with spare parts from 3rd party manufacturers. Especially, as this is does not catch the eye of the consumer, the equipment is assembled in large indivisible units.
Comparison of the use of disposable and classic versions of fermenters and bioreactors
Disposable culture systems are becoming increasingly prevalent compared to 10 years ago when it was used as a one-off production. Although, “classic” fermenters made from steel are still used everywhere, as they continue to equip their production facilities. Especially, due to their reliability and durability, alongside the main standard technological characteristics in design and processes.