Cell suspension culture technology has become a cornerstone of modern biopharmaceutical production. From its early use in vaccine development to its role in large-scale therapeutic antibody manufacturing, this technology has revolutionized the efficiency, scalability.
Achieving industrial-scale fermentation with consistent quality and high yield requires precise, adaptive, and intelligent process control strategies. For advanced fermentation engineers, mastering process control is no longer optional—it is the key to scaling up efficiently while maintaining genetic and metabolic stability.
idely used in industrial fermentation processes for recombinant protein production. Successful fermentation requires precise control over various parameters, including feed rate, oxygen levels, pH, temperature, and nutrient composition. This article explores key factors that influence E. coli fermentation and strategies to optimize protein expression.
Pichia pastoris is a methanol-tolerant yeast widely used for recombinant protein expression. This yeast can utilize methanol as its sole carbon and energy source, making it a preferred choice for industrial bioprocesses.
Food fermentation technology plays a crucial role in enhancing the flavor, texture, and nutritional value of food products. As advancements in biotechnology continue, the development of fermentation agents is moving towards greater precision, efficiency, and functionality.
Fermentation is a complex biochemical process that plays a crucial role in industries ranging from pharmaceuticals to food production. By leveraging cutting-edge software, researchers and manufacturers can achieve intelligent monitoring, prediction, and optimization of fermentation metabolism.
Microbial fermentation is a cornerstone of biotechnological research and industrial production. Among the most commonly used methods are shake flask culture and tank (bioreactor) culture, each offering distinct advantages and challenges.
The Internet of Things (IoT) is a paradigm that enables seamless interconnection of devices, providing remote monitoring and control capabilities. IoT primarily relies on Radio Frequency Identification (RFID) technology and is underpinned by advanced sensor technologies that offer the ability to measure and understand the physical world.
1. Product Description Erythritol is a naturally occurring polyol (sugar alcohol) that serves as a zero-calorie sweetener, making it an ideal ingredient for low-calorie foods and sugar-free beverages. It is found in various fruits such as pears, melons, and grapes, as well as in fermented products like wine, soy sauce, and cheese. With a sweetness…
A New Era in Meat Production As technology advances at an unprecedented pace, the food industry is undergoing a profound transformation. Imagine biting into a juicy burger that never saw a traditional slaughterhouse—one that was grown in a controlled environment rather than on a farm. This may sound like science fiction, but the rise of…
The development of antibody drugs relies on a well-structured Quality by Design (QbD) approach for upstream production. By leveraging the advantages of Design of Experiments (DoE) and high-throughput parallel bioreactor technology, researchers can efficiently complete laboratory-scale R&D processes. A critical step in this process is the early identification of the relationship between critical quality attributes…
The design of bioreactors is primarily determined by the method of energy supply and aeration of the medium. Based on these criteria, bioreactors can be categorized into the following types:
